KCNT1

Across TCGA patient cohorts, KCNT1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNT1-associated genes across cancer lineages are Caspase-7-cleavedD198, Paxillin, and Rab25. Each is linked with KCNT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNT1-to-partner and partner-to-KCNT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KCNT1-low versus KCNT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNT1→partner) and Y-score (partner→KCNT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.401	+1.415	.021	.040	3	3
LUAD	Paxillin →	-0.538	-3.000	.003	.036	3	2
LUAD	Rab25 →	+0.493	+3.000	.008	.036	3	2
LUAD	STAT3_pY705 →	-0.349	-3.000	.018	.036	3	2
SKCM	FoxM1 →	+0.174	+1.807	.012	.024	3	2
COAD	eIF4E →	+0.258	+2.725	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Caspase-7-cleavedD198 by KCNT1 expression — UCEC

Explore this box plot interactively →