potassium inwardly rectifying channel subfamily J member 4Genealiases: HIR · HIRK2 · HRK1 · IRK-3 · IRK3 · Kir2.3
Q-omics provides the consensus-scored KCNJ4 profile across patient tissues and cancer cell-line models. KCNJ4 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, KCNJ4 is differentially expressed in 10, with the highest sampling consensus in KICH. Additionally, KCNJ4 RNA expression shows 14,567 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and KICH as cancer lineages where KCNJ4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KCNJ4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KCNJ4 survival associations across molecular data types. KCNJ4 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (4) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KCNJ4 RNA expression–survival associations across cancer types. High KCNJ4 expression shows unfavorable associations in UVM, LUAD, BRCA and UCEC, but favorable associations in ACC and THYM. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for KCNJ4 RNA expression.
This table summarizes KCNJ4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for KCNJ4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KCNJ4 shows lower tumor expression in KICH and CHOL and higher tumor expression in KIRP, KIRC, HNSC and BRCA. The KICH box plot shows higher KCNJ4 RNA expression in normal versus tumor tissue (log2 FC = −0.566, t-test p < 0.001).
This table shows molecular features associated with KCNJ4 in patient tissues and cancer cell lines. In patient samples, KCNJ4 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, KCNJ4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and BONE.
