KCNJ4

Across TCGA patient cohorts, KCNJ4 mutation is significantly associated with the RNA expression of many other genes, with 4,376 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ4-associated genes across cancer lineages are L3MBTL2, ACO2, and CIRBP-AS1. Each is linked with KCNJ4 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNJ4-to-partner and partner-to-KCNJ4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L3MBTL2 grouped by KCNJ4-low versus KCNJ4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ4→partner) and Y-score (partner→KCNJ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	L3MBTL2 →	+0.408	+3.597	.001	.001	3	4
UCEC	ACO2 →	+0.554	+1.864	.004	.004	3	4
UCEC	CIRBP-AS1 →	+0.526	+2.656	<.001	<.001	3	4
READ	CDY3P →	+0.050	+7.276	<.001	<.001	3	3
UCEC	PPIL2 →	+0.383	+2.654	<.001	<.001	3	3
STAD	PLA2G3 →	+0.760	+3.622	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,376 associations by consensus.

L3MBTL2 by KCNJ4 expression — SKCM

Explore this box plot interactively →