KCNJ4

Across TCGA patient cohorts, KCNJ4 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ4-associated genes across cancer lineages are Lck, Di-Ras3, and PCNA. Each is linked with KCNJ4 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNJ4-to-partner and partner-to-KCNJ4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by KCNJ4-low versus KCNJ4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ4→partner) and Y-score (partner→KCNJ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Lck →	+0.363	+2.321	.005	.034	3	3
STAD	Di-Ras3 →	-0.135	-3.000	.013	.033	3	3
UCEC	PCNA →	+0.180	+2.000	.033	.030	3	3
STAD	eEF2 →	+0.372	+3.459	.006	.005	3	2
UCEC	Gab2 →	+0.291	+1.584	.037	.036	3	2
UCEC	MEK1 →	+0.367	+2.502	.010	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Lck by KCNJ4 expression — STAD

Explore this box plot interactively →