KCNJ4

Across TCGA cell cohorts, KCNJ4 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNJ4-associated genes across cancer lineages are NEUROD4, TKTL2, and MSGN1. Each is linked with KCNJ4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ4-to-partner and partner-to-KCNJ4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROD4 grouped by KCNJ4-low versus KCNJ4-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ4→partner) and Y-score (partner→KCNJ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NEUROD4 →	+0.196	+5.087	<.001	.004	3	1
LARGE_INTESTINE	TKTL2 →	+0.054	+4.187	<.001	.002	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	REG1B →	+3.867	+3.196	<.001	.007	3	1
LARGE_INTESTINE	PPP1R42 →	+0.098	+3.781	.001	.003	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

NEUROD4 by KCNJ4 expression — URINARY_TRACT

Explore this box plot interactively →