potassium voltage-gated channel modifier subfamily G member 4Genealiases: KV6.3 · KV6.4
Q-omics provides the consensus-scored KCNG4 profile across patient tissues and cancer cell-line models. KCNG4 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in READ. Among the 18 cancer types available for tumor–normal comparison, KCNG4 is differentially expressed in 5, with the highest sampling consensus in THCA. Additionally, KCNG4 RNA expression shows 6,703 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight READ, THCA, and STAD as cancer lineages where KCNG4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KCNG4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KCNG4 survival associations across molecular data types. KCNG4 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KCNG4 RNA expression–survival associations across cancer types. High KCNG4 expression shows unfavorable associations in READ, CHOL, ACC and UVM, but favorable associations in LUSC and UCS. The READ Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify READ as the clearest survival context for KCNG4 RNA expression.
This table summarizes KCNG4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for KCNG4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KCNG4 shows lower tumor expression in THCA, KICH and COAD and higher tumor expression in KIRP and LIHC. The THCA box plot shows higher KCNG4 RNA expression in normal versus tumor tissue (log2 FC = −0.075, t-test p = .002).
This table shows molecular features associated with KCNG4 in patient tissues and cancer cell lines. In patient samples, KCNG4 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set. In cancer cell lines, KCNG4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and LARGE_INTESTINE.
