KCNG4

Across TCGA pan-cancer cohorts, KCNG4 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of KCNG4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where KCNG4 RNA is repressed in tumor relative to normal tissue. In most cancer types KCNG4 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRP are the cancer types where KCNG4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNG4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.075	.002	4	view →
KICH	All	All	−0.005	.024	2	view →
KIRP	Female	All	+0.029	.010	1	view →
LIHC	Male	All	+0.003	.039	1	view →
COAD	Female	II,III,IV	−0.003	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

KCNG4–THCA

Open the THCA breakdown →