Q-omics provides the consensus-scored HOMEZ profile across patient tissues and cancer cell-line models. HOMEZ expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in BRCA. Among the 18 cancer types available for tumor–normal comparison, HOMEZ is differentially expressed in 12, with the highest sampling consensus in KIRC. Additionally, HOMEZ RNA expression shows 19,768 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight BRCA, KIRC, and ACC as cancer lineages where HOMEZ shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HOMEZ — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HOMEZ survival associations across molecular data types. HOMEZ RNA expression shows survival associations in the most cancer types (19), followed by mutation status (4) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HOMEZ RNA expression–survival associations across cancer types. High HOMEZ expression shows unfavorable associations in LIHC and ACC, but favorable associations in BRCA, KIRC, MESO and SCLC. The BRCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify BRCA as the clearest survival context for HOMEZ RNA expression.
This table summarizes HOMEZ tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for HOMEZ. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HOMEZ shows lower tumor expression in KIRC and THCA and higher tumor expression in LIHC, BRCA, HNSC and LUSC. The KIRC box plot shows higher HOMEZ RNA expression in normal versus tumor tissue (log2 FC = −0.682, t-test p < 0.001).
This table shows molecular features associated with HOMEZ in patient tissues and cancer cell lines. In patient samples, HOMEZ shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, HOMEZ RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Myeloma and BLOOD_Leukemia.
