Across TCGA cell cohorts, HOMEZ mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOMEZ-associated genes across cancer lineages are SPAM1, G6PC2, and TSGA13. Each is linked with HOMEZ in more than 1 cancer types. Because this analysis shows association rather than direction, both HOMEZ-to-partner and partner-to-HOMEZ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOMEZ→partner) and Y-score (partner→HOMEZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SPAM1 →	+0.032	+4.044	<.001	.003	3	1
STOMACH	G6PC2 →	+0.060	+3.857	<.001	.004	3	1
STOMACH	TSGA13 →	+0.017	+3.632	<.001	.009	3	1
LARGE_INTESTINE	REG1B →	+1.730	+3.196	.008	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.977	<.001	.001	3	1
LARGE_INTESTINE	OR4F4 →	+0.014	+3.688	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

HOMEZ survival (RNA) · tumor vs normal (RNA) · all HOMEZ data types