Across TCGA patient cohorts, HOMEZ mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOMEZ-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and HER3_pY1289. Each is linked with HOMEZ in more than 1 cancer types. Because this analysis shows association rather than direction, both HOMEZ-to-partner and partner-to-HOMEZ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOMEZ→partner) and Y-score (partner→HOMEZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.178	+2.000	.031	.010	3	1
UCEC	A-Raf_pS299 →	-0.097	-2.321	.039	.034	3	1
UCEC	HER3_pY1289 →	+0.082	+2.341	.015	.019	3	1
UCEC	MEK1 →	+0.450	+3.906	.001	<.001	3	1
UCEC	p21 →	+0.173	+2.820	.022	.035	3	1
UCEC	p62 Lck ligand →	+0.430	+2.502	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

HOMEZ survival (RNA) · tumor vs normal (RNA) · all HOMEZ data types