Across TCGA patient cohorts, HOMEZ protein abundance is significantly associated with the RNA expression of many other genes, with 5,872 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HOMEZ-associated genes across cancer lineages are NGDN, HECTD1, and ARHGDIB. Each is linked with HOMEZ in more than 4 cancer types. Because this analysis shows association rather than direction, both HOMEZ-to-partner and partner-to-HOMEZ results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOMEZ→partner) and Y-score (partner→HOMEZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NGDN →	+0.739	+0.269	.002	<.001	3	5
GBM	HECTD1 →	+0.640	+0.343	.004	.001	3	3
GBM	ARHGDIB →	-2.110	-0.363	.005	<.001	3	3
GBM	CD300C →	-2.333	-0.363	.005	<.001	3	3
GBM	CD74 →	-3.420	-0.363	<.001	<.001	3	3
GBM	SIGLEC14 →	-2.283	-0.363	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,872 associations by consensus.

Exploration

HOMEZ survival (RNA) · tumor vs normal (RNA) · all HOMEZ data types