Q-omics provides the consensus-scored HMBOX1 profile across patient tissues and cancer cell-line models. HMBOX1 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, HMBOX1 is differentially expressed in 10, with the highest sampling consensus in THCA. Additionally, HMBOX1 RNA expression shows 20,738 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight HNSC, THCA, and THYM as cancer lineages where HMBOX1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HMBOX1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HMBOX1 survival associations across molecular data types. HMBOX1 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (3) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HMBOX1 RNA expression–survival associations across cancer types. High HMBOX1 expression shows unfavorable associations in KICH, LIHC and BLCA, but favorable associations in HNSC, KIRC and READ. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for HMBOX1 RNA expression.
This table summarizes HMBOX1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 4. The strongest signals are observed in THCA for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for HMBOX1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HMBOX1 shows lower tumor expression in THCA, LUAD, BRCA and LUSC and higher tumor expression in LIHC and CHOL. The THCA box plot shows higher HMBOX1 RNA expression in normal versus tumor tissue (log2 FC = −0.938, t-test p < 0.001).
This table shows molecular features associated with HMBOX1 in patient tissues and cancer cell lines. In patient samples, HMBOX1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, HMBOX1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and STOMACH.
