HMBOX1

Across TCGA cell cohorts, HMBOX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,271 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HMBOX1-associated GO terms across cancer lineages are Negative regulation of maintenance of sister chromatid cohesion, Negative regulation of maintenance of mitotic sister chromatid cohesion, and Cilium or flagellum-dependent cell motility. Each is linked with HMBOX1 in more than 14 cancer types. Because this analysis shows association rather than direction, both HMBOX1-to-partner and partner-to-HMBOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of maintenance of sister chromatid cohesion grouped by HMBOX1-low versus HMBOX1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMBOX1→partner) and Y-score (partner→HMBOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of maintenance of sister chromatid cohesion →	+0.193	+1.149	<.001	.001	3	15
BONE	Negative regulation of maintenance of mitotic sister chromatid cohesion →	+0.193	+1.149	<.001	.001	3	15
OESOPHAGUS	Cilium or flagellum-dependent cell motility →	-0.083	-0.672	.009	.002	3	14
BONE	Pre-mRNA catabolic process →	+0.160	+0.848	.001	<.001	3	14
BONE	Positive regulation of double-strand break repair →	+0.088	+0.897	.002	<.001	3	14
STOMACH	Negative regulation of telomere maintenance →	+0.067	+0.845	.003	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,271 associations by consensus.

Negative regulation of maintenance of sister chromatid cohesion by HMBOX1 expression — BONE

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