HMBOX1

Across TCGA patient cohorts, HMBOX1 mutation is significantly associated with the RNA expression of many other genes, with 1,222 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMBOX1-associated genes across cancer lineages are MIR3929, RNU6-937P, and RNU6-1067P. Each is linked with HMBOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMBOX1-to-partner and partner-to-HMBOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3929 grouped by HMBOX1-low versus HMBOX1-high in SARC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMBOX1→partner) and Y-score (partner→HMBOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	MIR3929 →	+0.752	+5.477	<.001	.004	3	2
UCEC	RNU6-937P →	+0.343	+1.815	.003	.003	3	2
CESC	RNU6-1067P →	+0.548	+4.984	<.001	.003	3	2
LUAD	RNA5SP408 →	+0.308	+7.930	<.001	.008	3	2
LUSC	OR8K5 →	+0.251	+4.882	<.001	.005	3	2
SKCM	LINC02272 →	+0.031	+4.624	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,222 associations by consensus.

MIR3929 by HMBOX1 expression — SARC

Explore this box plot interactively →