HMBOX1

Across TCGA patient cohorts, HMBOX1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMBOX1-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and INPP4B. Each is linked with HMBOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMBOX1-to-partner and partner-to-HMBOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by HMBOX1-low versus HMBOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMBOX1→partner) and Y-score (partner→HMBOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.093	-2.432	.021	.018	3	1
UCEC	EGFR_pY1068 →	-0.274	-3.169	.006	.018	3	1
UCEC	INPP4B →	-0.298	-3.169	.022	.018	3	1
UCEC	MEK1 →	+0.432	+1.906	.003	.016	3	1
UCEC	Myosin-IIa →	+0.182	+3.332	.014	.005	3	1
UCEC	PCNA →	+0.194	+2.700	.025	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

14-3-3_beta by HMBOX1 expression — UCEC

Explore this box plot interactively →