HMBOX1

Across TCGA patient cohorts, HMBOX1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,156 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HMBOX1-associated proteins across cancer lineages are CCAR2, XPO7, and CCDC25. Each is linked with HMBOX1 in more than 7 cancer types. Because this analysis shows association rather than direction, both HMBOX1-to-partner and partner-to-HMBOX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMBOX1 versus CCAR2 in HNSC, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMBOX1→partner) and Y-score (partner→HMBOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCAR2 →	+0.460	+0.782	<.001	<.001	3	8
BRCA	XPO7 →	+0.350	+0.483	<.001	<.001	3	6
OV	CCDC25 →	+0.347	+0.741	<.001	<.001	3	6
PDAC	PPP2R2A →	+0.405	+0.337	<.001	<.001	3	6
HNSC	MYEF2 →	+0.980	+0.437	<.001	.002	3	5
BRCA	NEIL2 →	+0.486	+0.549	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,156 associations by consensus.

HMBOX1 vs CCAR2 — HNSC

Explore this scatter interactively →