HMBOX1

Across TCGA patient cohorts, HMBOX1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,200 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HMBOX1-associated genes across cancer lineages are INTS9, CCDC25, and DDHD2. Each is linked with HMBOX1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HMBOX1-to-partner and partner-to-HMBOX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMBOX1 versus INTS9 in BRCA, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMBOX1→partner) and Y-score (partner→HMBOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	INTS9 →	+0.574	+0.524	<.001	.001	3	5
BRCA	CCDC25 →	+0.463	+0.414	.001	.001	3	5
LUAD	DDHD2 →	+0.442	+0.247	<.001	.001	3	4
CCRCC	LEPROTL1 →	+0.500	+0.413	<.001	<.001	3	4
CCRCC	DCTN6 →	+0.533	+0.609	<.001	<.001	3	4
BRCA	PCM1 →	+0.754	+0.516	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,200 associations by consensus.

HMBOX1 vs INTS9 — BRCA

Explore this scatter interactively →