major histocompatibility complex, class II, DR beta 5Genealiases: DRB5 · HLA-DRB5*
Q-omics provides the consensus-scored HLA-DRB5 profile across patient tissues and cancer cell-line models. HLA-DRB5 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, HLA-DRB5 is differentially expressed in 8, with the highest sampling consensus in LUAD. Additionally, HLA-DRB5 protein abundance shows 16,097 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRC, LUAD, and LSCC as cancer lineages where HLA-DRB5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HLA-DRB5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HLA-DRB5 survival associations across molecular data types. HLA-DRB5 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (1) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HLA-DRB5 RNA expression–survival associations across cancer types. High HLA-DRB5 expression shows unfavorable associations in UVM and LGG, but favorable associations in KIRC, SKCM, HNSC and LUAD. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for HLA-DRB5 RNA expression.
This table summarizes HLA-DRB5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for HLA-DRB5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HLA-DRB5 shows lower tumor expression in LUAD, LUSC, KICH and PAAD and higher tumor expression in KIRC and THCA. The LUAD box plot shows higher HLA-DRB5 RNA expression in normal versus tumor tissue (log2 FC = −2.034, t-test p < 0.001).
This table shows molecular features associated with HLA-DRB5 in patient tissues and cancer cell lines. In patient samples, HLA-DRB5 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, HLA-DRB5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and UPPER_AERODIGESTIVE_TRACT.
