Across TCGA pan-cancer cohorts, HLA-DRB5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HLA-DRB5 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HLA-DRB5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HLA-DRB5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

COAD, PDAC, and CCRCC are the cancer types where HLA-DRB5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.827	1.000	.014	48	view →
PDAC	OS	Quartile	III,IV	0.701	0.354	.015	10	view →
CCRCC	DFS	Quartile	II,III,IV	0.981	0.209	.024	7	view →
LUAD	OS	Median	II,III,IV	0.832	0.458	.043	2	view →
LSCC	OS	Median	III,IV	0.932	0.783	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: HLA-DRB5 tumor-vs-normal RNA expression · all HLA-DRB5 data types