Across TCGA pan-cancer cohorts, HLA-DRB5 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated HLA-DRB5 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HLA-DRB5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-DRB5 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, SKCM, and HNSC are the cancer types where HLA-DRB5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.695	0.555	<.001	114	view →
SKCM	OS	Median	All	0.433	0.267	<.001	109	view →
HNSC	DFS	Quartile	All	0.685	0.506	<.001	88	view →
UVM	DFS	Median	All	0.376	0.772	<.001	60	view →
LUAD	DFS	Median	All	0.733	0.595	<.001	57	view →
LGG	OS	Median	All	0.380	0.513	<.001	49	view →
UCEC	DFS	Quartile	All	0.689	0.540	.002	38	view →
LAML	DFS	Quartile	All	0.294	0.688	<.001	38	view →
LIHC	DFS	Quartile	II,III,IV	0.529	0.271	<.001	36	view →
UCS	DFS	Tertile	IV	0.956	0.380	.024	24	view →
THYM	OS	Median	II,III,IV	0.610	0.959	.002	23	view →
BRCA	DFS	Median	All	0.599	0.463	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

Exploration

Same gene, other analysis: HLA-DRB5 tumor-vs-normal RNA expression · all HLA-DRB5 data types