Across TCGA patient cohorts, HLA-DRB5 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,786 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DRB5-associated proteins across cancer lineages are HLA-DRA, HLA-DMA, and HLA-DQB1. Each is linked with HLA-DRB5 in more than 8 cancer types. Because this analysis shows association rather than direction, both HLA-DRB5-to-partner and partner-to-HLA-DRB5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRB5→partner) and Y-score (partner→HLA-DRB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HLA-DRA →	+0.696	+1.291	<.001	<.001	3	9
GBM	HLA-DMA →	+0.823	+1.698	<.001	<.001	3	8
LSCC	HLA-DQB1 →	+1.300	+1.822	<.001	<.001	3	8
COAD	HLA-DRB1 →	+0.678	+1.642	<.001	<.001	3	8
HNSC	PARVG →	+0.470	+1.918	<.001	<.001	3	7
LSCC	ARHGAP45_S569 →	+0.659	+1.179	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,786 associations by consensus.

Exploration

HLA-DRB5 survival (RNA) · tumor vs normal (RNA) · all HLA-DRB5 data types