Across TCGA patient cohorts, HLA-DRB5 protein abundance is significantly associated with the RNA expression of many other genes, with 10,381 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DRB5-associated genes across cancer lineages are HLA-DOA, HLA-DRA, and HLA-DPB1. Each is linked with HLA-DRB5 in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DRB5-to-partner and partner-to-HLA-DRB5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRB5→partner) and Y-score (partner→HLA-DRB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HLA-DOA →	+1.123	+0.671	<.001	<.001	3	10
UCEC	HLA-DRA →	+1.569	+0.985	<.001	<.001	3	10
GBM	HLA-DPB1 →	+0.989	+0.894	<.001	<.001	3	10
UCEC	CD74 →	+1.374	+1.190	<.001	<.001	3	9
UCEC	HLA-DMA →	+1.473	+1.026	<.001	<.001	3	9
GBM	CD4 →	+0.955	+0.873	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,381 associations by consensus.

Exploration

HLA-DRB5 survival (RNA) · tumor vs normal (RNA) · all HLA-DRB5 data types