G protein-coupled receptor 148Genealiases: BTR · PGR6
Q-omics provides the consensus-scored GPR148 profile across patient tissues and cancer cell-line models. GPR148 expression is associated with patient survival in 15 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, GPR148 is differentially expressed in 3, with the highest sampling consensus in THCA. Additionally, GPR148 RNA expression shows 6,838 significant pathway-activity associations, with the highest sampling consensus in UCEC. Together, these results highlight KIRP, THCA, and UCEC as cancer lineages where GPR148 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for GPR148 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes GPR148 survival associations across molecular data types. GPR148 RNA expression shows survival associations in the most cancer types (15), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible GPR148 RNA expression–survival associations across cancer types. High GPR148 expression shows unfavorable associations in KIRP, LIHC, ACC and THYM, but favorable associations in LGG and PAAD. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for GPR148 RNA expression.
This table summarizes GPR148 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for GPR148. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. GPR148 shows lower tumor expression in THCA, KIRC and STAD. The THCA box plot shows higher GPR148 RNA expression in normal versus tumor tissue (log2 FC = −0.006, t-test p = .025).
This table shows molecular features associated with GPR148 in patient tissues and cancer cell lines. In patient samples, GPR148 shows the broadest associations at the RNA and protein expression levels, with UCEC recurring as the lineage with the largest associated feature set. In cancer cell lines, GPR148 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in SKIN and LARGE_INTESTINE.
