GPR148

Across TCGA cell cohorts, GPR148 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GPR148-associated genes across cancer lineages are SHCBP1L, FAM240A, and CER1. Each is linked with GPR148 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR148-to-partner and partner-to-GPR148 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHCBP1L grouped by GPR148-low versus GPR148-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR148→partner) and Y-score (partner→GPR148) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SHCBP1L →	+0.810	+4.212	.002	.007	3	1
LUNG_NSCLC_LUAD	FAM240A →	+0.005	+5.266	<.001	.001	3	1
BLOOD_Lymphoma	CER1 →	+0.029	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	TRIM60 →	+0.345	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	DPPA3 →	+0.020	+6.247	<.001	<.001	3	1
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SHCBP1L by GPR148 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →