GPR148

Across TCGA pan-cancer cohorts, GPR148 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated GPR148 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher GPR148 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR148 expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

KIRP, LGG, and ACC are the cancer types where GPR148 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.716	0.941	<.001	93	view →
LGG	DFS	Median	All	0.805	0.672	<.001	44	view →
ACC	DFS	Tertile	All	0.200	0.628	<.001	36	view →
LIHC	OS	Tertile	III,IV	0.118	0.615	.003	36	view →
PAAD	DFS	Median	All	0.410	0.176	<.001	22	view →
THYM	DFS	Tertile	II,III,IV	0.145	0.873	<.001	18	view →
PRAD	OS	Quartile	All	0.966	0.997	.005	14	view →
KIRC	DFS	Tertile	IV	0.347	0.560	.045	12	view →
READ	DFS	Tertile	All	0.221	0.614	.008	9	view →
GBM	OS	Tertile	All	0.137	0.426	.017	9	view →
SCLC	OS	Tertile	All	0.491	0.256	.023	7	view →
UCS	OS	Tertile	II,III,IV	0.687	0.298	.045	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

GPR148–KIRP (DFS)

Open the KIRP breakdown →