golgin, RAB6 interactingGenealiases: GO · NTKLBP1 · SCYL1BP1
Q-omics provides the consensus-scored GORAB profile across patient tissues and cancer cell-line models. GORAB expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, GORAB is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, GORAB protein abundance shows 21,560 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight KIRP, HNSC, and LUAD as cancer lineages where GORAB shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for GORAB — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes GORAB survival associations across molecular data types. GORAB RNA expression shows survival associations in the most cancer types (24), followed by mutation status (3) and mass-spec protein abundance (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible GORAB RNA expression–survival associations across cancer types. High GORAB expression shows unfavorable associations in KIRP, LIHC, ACC and KIRC, but favorable associations in SKCM and HNSC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for GORAB RNA expression.
This table summarizes GORAB tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 8. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for GORAB. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. GORAB shows lower tumor expression in THCA and higher tumor expression in HNSC, BLCA, LIHC, LUAD and STAD. The HNSC box plot shows higher GORAB RNA expression in tumor versus normal tissue (log2 FC = +1.117, t-test p < 0.001).
This table shows molecular features associated with GORAB in patient tissues and cancer cell lines. In patient samples, GORAB shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set. In cancer cell lines, GORAB RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and UPPER_AERODIGESTIVE_TRACT.
