GORAB

Across TCGA cell cohorts, GORAB mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GORAB-associated genes across cancer lineages are Niraparib, BMS-345541, and VE-822. Each is linked with GORAB in more than 1 cancer types. Because this analysis shows association rather than direction, both GORAB-to-partner and partner-to-GORAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by GORAB-low versus GORAB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GORAB→partner) and Y-score (partner→GORAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.352	+2.868	.037	.022	3	1
LARGE_INTESTINE	BMS-345541 →	+0.520	+2.868	.029	.022	3	1
LARGE_INTESTINE	VE-822 →	+0.620	+2.868	.022	.022	3	1
LARGE_INTESTINE	Idelalisib →	+0.471	+2.652	.015	.045	3	1
LARGE_INTESTINE	CX-5461 →	+0.632	+2.652	.032	.045	3	1
LARGE_INTESTINE	WYE-125132 →	+0.622	+2.652	.014	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Niraparib by GORAB expression — LARGE_INTESTINE

Explore this box plot interactively →