GORAB

Across TCGA patient cohorts, GORAB mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GORAB-associated genes across cancer lineages are A-Raf_pS299, 14-3-3_beta, and eEF2. Each is linked with GORAB in more than 1 cancer types. Because this analysis shows association rather than direction, both GORAB-to-partner and partner-to-GORAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by GORAB-low versus GORAB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GORAB→partner) and Y-score (partner→GORAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.159	-2.321	.004	.034	3	2
UCEC	14-3-3_beta →	-0.132	-3.295	.005	.009	3	1
UCEC	eEF2 →	+0.446	+3.000	.007	.036	2	2
UCEC	EGFR_pY1068 →	-0.287	-3.000	.014	.036	3	1
UCEC	PCNA →	+0.211	+2.584	.036	.011	3	1
UCEC	Annexin-1 →	+0.777	+3.189	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

A-Raf_pS299 by GORAB expression — UCEC

Explore this box plot interactively →