GORAB

Across TCGA patient cohorts, GORAB mutation is significantly associated with the RNA expression of many other genes, with 727 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GORAB-associated genes across cancer lineages are RNA5SP413, RNA5SP423, and MDH1P2. Each is linked with GORAB in more than 1 cancer types. Because this analysis shows association rather than direction, both GORAB-to-partner and partner-to-GORAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by GORAB-low versus GORAB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GORAB→partner) and Y-score (partner→GORAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP413 →	+1.103	+1.862	<.001	.004	3	2
UCEC	RNA5SP423 →	+0.728	+2.302	<.001	<.001	3	2
COAD	MDH1P2 →	+0.117	+3.622	<.001	.002	3	2
UCEC	IDI2-AS1 →	+0.237	+2.184	<.001	.002	3	2
UCEC	RNA5SP408 →	+0.228	+2.508	.007	.003	3	2
UCEC	RNU6-158P →	+0.304	+2.167	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 727 associations by consensus.

RNA5SP413 by GORAB expression — UCEC

Explore this box plot interactively →