filamin A interacting protein 1Genealiases: FILIP · NMDF
Q-omics provides the consensus-scored FILIP1 profile across patient tissues and cancer cell-line models. FILIP1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, FILIP1 is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, FILIP1 protein abundance shows 23,184 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRC, and LSCC as cancer lineages where FILIP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FILIP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FILIP1 survival associations across molecular data types. FILIP1 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (7) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FILIP1 RNA expression–survival associations across cancer types. High FILIP1 expression shows unfavorable associations in UVM, MESO and BLCA, but favorable associations in KIRC, OV and UCS. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for FILIP1 RNA expression.
This table summarizes FILIP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for FILIP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FILIP1 shows lower tumor expression in BLCA, COAD, LUAD, LUSC and THCA and higher tumor expression in KIRC. The KIRC box plot shows higher FILIP1 RNA expression in tumor versus normal tissue (log2 FC = +1.265, t-test p < 0.001).
This table shows molecular features associated with FILIP1 in patient tissues and cancer cell lines. In patient samples, FILIP1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, FILIP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in OVARY and LARGE_INTESTINE.
