FILIP1

Across TCGA patient cohorts, FILIP1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FILIP1-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with FILIP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FILIP1-to-partner and partner-to-FILIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FILIP1-low versus FILIP1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FILIP1→partner) and Y-score (partner→FILIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eIF4E →	+0.229	+3.000	.014	.036	3	4
UCEC	Caspase-7-cleavedD198 →	+0.481	+1.097	.003	.048	3	3
UCEC	4E-BP1 →	+0.243	+2.169	.001	.002	3	3
COAD	4E-BP1_pT70 →	+0.108	+2.321	.012	.033	3	3
UCEC	PDCD4 →	-0.317	-1.280	.016	.049	3	2
UCEC	PDK1_pS241 →	+0.133	+1.716	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eIF4E by FILIP1 expression — STAD

Explore this box plot interactively →