FILIP1

Across TCGA cell cohorts, FILIP1 mutation is significantly associated with the RNA expression of many other genes, with 877 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FILIP1-associated genes across cancer lineages are GUCA1A, CCDC179, and GSTA3. Each is linked with FILIP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FILIP1-to-partner and partner-to-FILIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA1A grouped by FILIP1-low versus FILIP1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FILIP1→partner) and Y-score (partner→FILIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GUCA1A →	+1.949	+2.996	<.001	<.001	3	3
SKIN	CCDC179 →	+0.050	+2.004	.002	.007	2	3
STOMACH	GSTA3 →	+0.072	+3.099	.006	.006	3	2
CNS	PLPPR1 →	+1.289	+2.951	<.001	.004	3	2
CNS	LRIT1 →	+0.371	+2.874	.002	.003	3	2
BLOOD_Leukemia	SLC5A12 →	+0.432	+3.526	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 877 associations by consensus.

GUCA1A by FILIP1 expression — CNS

Explore this box plot interactively →