FILIP1

Across TCGA patient cohorts, FILIP1 mutation is significantly associated with the RNA expression of many other genes, with 3,455 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FILIP1-associated genes across cancer lineages are GOT1, PPIP5K1, and ZNF439. Each is linked with FILIP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FILIP1-to-partner and partner-to-FILIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT1 grouped by FILIP1-low versus FILIP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FILIP1→partner) and Y-score (partner→FILIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GOT1 →	+0.518	+2.529	<.001	.001	3	4
COAD	PPIP5K1 →	+0.359	+2.515	<.001	.001	3	4
UCEC	ZNF439 →	-0.501	-2.279	<.001	<.001	3	4
SKCM	HMG20B →	+0.347	+1.360	.003	<.001	3	4
UCEC	EBF4 →	-0.527	-2.003	.006	.005	3	4
COAD	TMEM87A →	+0.465	+3.651	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,455 associations by consensus.

GOT1 by FILIP1 expression — COAD

Explore this box plot interactively →