family with sequence similarity 43 member AGenealiases: []
Q-omics provides the consensus-scored FAM43A profile across patient tissues and cancer cell-line models. FAM43A expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, FAM43A is differentially expressed in 14, with the highest sampling consensus in THCA. Additionally, FAM43A RNA expression shows 18,534 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight BLCA, THCA, and ACC as cancer lineages where FAM43A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM43A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM43A survival associations across molecular data types. FAM43A RNA expression shows survival associations in the most cancer types (25), followed by mutation status (2) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM43A RNA expression–survival associations across cancer types. High FAM43A expression shows unfavorable associations in BLCA, ACC, UVM and LGG, but favorable associations in KIRC and STAD. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify BLCA as the clearest survival context for FAM43A RNA expression.
This table summarizes FAM43A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 3. The strongest signals are observed in THCA for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for FAM43A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM43A shows lower tumor expression in KICH, LUAD, KIRP and BLCA and higher tumor expression in THCA and LIHC. The THCA box plot shows higher FAM43A RNA expression in tumor versus normal tissue (log2 FC = +2.953, t-test p < 0.001).
This table shows molecular features associated with FAM43A in patient tissues and cancer cell lines. In patient samples, FAM43A shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM43A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and SKIN.
