family with sequence similarity 120 member CGenealiases: CXorf17 · ORF34
Q-omics provides the consensus-scored FAM120C profile across patient tissues and cancer cell-line models. FAM120C expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, FAM120C is differentially expressed in 10, with the highest sampling consensus in KIRC. Additionally, FAM120C RNA expression shows 20,651 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and KIRC as cancer lineages where FAM120C shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM120C — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM120C survival associations across molecular data types. FAM120C RNA expression shows survival associations in the most cancer types (21), followed by mutation status (4) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM120C RNA expression–survival associations across cancer types. High FAM120C expression shows unfavorable associations in UVM, STAD and COAD, but favorable associations in KIRC, ACC and SKCM. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for FAM120C RNA expression.
This table summarizes FAM120C tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for FAM120C. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM120C shows lower tumor expression in KIRC and BLCA and higher tumor expression in LIHC, COAD, CHOL and BLCA. The KIRC box plot shows higher FAM120C RNA expression in normal versus tumor tissue (log2 FC = −0.385, t-test p < 0.001).
This table shows molecular features associated with FAM120C in patient tissues and cancer cell lines. In patient samples, FAM120C shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM120C RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Lymphoma, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and LARGE_INTESTINE.
