Across TCGA pan-cancer cohorts, FAM120C Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FAM120C data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FAM120C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM120C expression acts as an unfavorable survival marker, although some lineages such as SCLC show a favorable association.

COAD, UCEC, and ESCA are the cancer types where FAM120C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.056	0.793	<.001	24	view →
UCEC	OS	Median	IV	0.225	0.772	<.001	12	view →
ESCA	OS	Median	All	0.147	0.700	.002	6	view →
SCLC	DFS	Median	All	1.000	0.259	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: FAM120C tumor-vs-normal RNA expression · all FAM120C data types