Across TCGA patient cohorts, FAM120C mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM120C-associated genes across cancer lineages are Di-Ras3, eIF4E, and ERK2. Each is linked with FAM120C in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM120C-to-partner and partner-to-FAM120C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM120C→partner) and Y-score (partner→FAM120C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.131	-2.209	.005	.009	3	3
UCEC	eIF4E →	+0.160	+1.523	.017	.008	3	2
UCEC	ERK2 →	+0.175	+2.807	.004	.002	3	2
UCEC	MEK1 →	+0.265	+2.662	.023	<.001	3	2
UCEC	mTOR_pS2448 →	-0.136	-1.906	.004	.004	3	2
UCEC	Notch1 →	+0.203	+2.378	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

FAM120C survival (RNA) · tumor vs normal (RNA) · all FAM120C data types