Across TCGA pan-cancer cohorts, FAM120C RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FAM120C data layer compared with 4 for mutation status and 6 for mass-spec protein.
The strongest signal is observed in uveal melanoma (UVM), where higher FAM120C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM120C expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.
UVM, STAD, and COAD are the cancer types where FAM120C RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.