Q-omics provides the consensus-scored COG7 profile across patient tissues and cancer cell-line models. COG7 expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, COG7 is differentially expressed in 14, with the highest sampling consensus in LIHC. Additionally, COG7 protein abundance shows 22,375 significant protein co-abundance associations, with the highest sampling consensus in CCRCC. Together, these results highlight KIRC, LIHC, and CCRCC as cancer lineages where COG7 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for COG7 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes COG7 survival associations across molecular data types. COG7 RNA expression shows survival associations in the most cancer types (18), followed by mutation status (5) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible COG7 RNA expression–survival associations across cancer types. High COG7 expression shows unfavorable associations in UVM, LIHC, LGG and BLCA, but favorable associations in KIRC and BRCA. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify KIRC as the clearest survival context for COG7 RNA expression.
This table summarizes COG7 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 5. The strongest signals are observed in LIHC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for COG7. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. COG7 shows lower tumor expression in KICH and THCA and higher tumor expression in LIHC, BRCA, CHOL and STAD. The LIHC box plot shows higher COG7 RNA expression in tumor versus normal tissue (log2 FC = +0.989, t-test p < 0.001).
This table shows molecular features associated with COG7 in patient tissues and cancer cell lines. In patient samples, COG7 shows the broadest associations at the RNA and protein expression levels, with CCRCC recurring as the lineage with the largest associated feature set. In cancer cell lines, COG7 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and UPPER_AERODIGESTIVE_TRACT.
