COG7

Across TCGA patient cohorts, COG7 mutation is significantly associated with the RNA expression of many other genes, with 1,003 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COG7-associated genes across cancer lineages are RN7SL104P, OR13Z3P, and CCDC137P. Each is linked with COG7 in more than 2 cancer types. Because this analysis shows association rather than direction, both COG7-to-partner and partner-to-COG7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL104P grouped by COG7-low versus COG7-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG7→partner) and Y-score (partner→COG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL104P →	+0.175	+3.735	.004	.005	3	3
BRCA	OR13Z3P →	+0.214	+5.064	<.001	.004	3	2
BRCA	CCDC137P →	+0.070	+4.635	<.001	.004	3	2
BRCA	TUBBP11 →	+0.268	+5.786	<.001	.001	3	2
SKCM	MIR4510 →	+0.090	+3.784	<.001	.009	3	2
UCEC	NECTIN4 →	-0.754	-3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,003 associations by consensus.

RN7SL104P by COG7 expression — BLCA

Explore this box plot interactively →