COG7

Across TCGA pan-cancer cohorts, COG7 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated COG7 data layer compared with 18 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher COG7 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COG7 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, LUAD, and LSCC are the cancer types where COG7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.922	.017	30	view →
LUAD	OS	Median	III,IV	0.823	0.425	.001	25	view →
LSCC	DFS	Median	All	0.393	0.922	.001	23	view →
HNSC	DFS	Median	II,III,IV	0.851	0.697	.009	9	view →
PDAC	OS	Median	IV	0.491	0.836	.024	6	view →
CCRCC	OS	Quartile	All	0.740	0.947	.033	3	view →
UCEC	DFS	Tertile	All	0.945	0.835	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

COG7–COAD (DFS)

Open the COAD breakdown →