COG7

Across TCGA cell cohorts, COG7 mutation is significantly associated with the RNA expression of many other genes, with 467 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COG7-associated genes across cancer lineages are PABPC1L2B, OR11H2, and SEMG1. Each is linked with COG7 in more than 1 cancer types. Because this analysis shows association rather than direction, both COG7-to-partner and partner-to-COG7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PABPC1L2B grouped by COG7-low versus COG7-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG7→partner) and Y-score (partner→COG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PABPC1L2B →	+0.017	+3.688	<.001	.002	3	2
BLOOD_Lymphoma	OR11H2 →	+0.031	+3.342	<.001	.008	3	1
SKIN	SEMG1 →	+0.015	+3.345	<.001	.007	3	1
SKIN	IRGC →	+0.011	+3.196	.009	.007	3	1
SKIN	CRISP2 →	+0.203	+3.789	<.001	.004	3	1
SKIN	NPBWR2 →	+0.031	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 467 associations by consensus.

PABPC1L2B by COG7 expression — SKIN

Explore this box plot interactively →