cap methyltransferase 1Genealiases: FTSJD2 · KIAA0082 · MTr1 · hMTr1
Q-omics provides the consensus-scored CMTR1 profile across patient tissues and cancer cell-line models. CMTR1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, CMTR1 is differentially expressed in 11, with the highest sampling consensus in HNSC. Additionally, CMTR1 protein abundance shows 20,924 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, HNSC, and GBM as cancer lineages where CMTR1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CMTR1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CMTR1 survival associations across molecular data types. CMTR1 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (4) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CMTR1 RNA expression–survival associations across cancer types. High CMTR1 expression shows unfavorable associations in COAD, UCEC and KICH, but favorable associations in KIRC, READ and SCLC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify KIRC as the clearest survival context for CMTR1 RNA expression.
This table summarizes CMTR1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 6. The strongest signals are observed in HNSC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for CMTR1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CMTR1 shows lower tumor expression in KICH and THCA and higher tumor expression in HNSC, COAD, LIHC and CHOL. The HNSC box plot shows higher CMTR1 RNA expression in tumor versus normal tissue (log2 FC = +0.871, t-test p < 0.001).
This table shows molecular features associated with CMTR1 in patient tissues and cancer cell lines. In patient samples, CMTR1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, CMTR1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in SKIN and BLOOD_Leukemia.
