CMTR1

Across TCGA patient cohorts, CMTR1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMTR1-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and PRDX1. Each is linked with CMTR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CMTR1-to-partner and partner-to-CMTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CMTR1-low versus CMTR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMTR1→partner) and Y-score (partner→CMTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.234	+2.137	.001	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.581	+2.107	.003	.002	3	3
COAD	PRDX1 →	+0.192	+2.195	.007	.034	3	2
COAD	ASNS →	+0.543	+2.178	.003	.035	3	2
UCEC	GAPDH →	+0.586	+2.415	.001	.003	3	2
UCEC	mTOR_pS2448 →	-0.157	-3.794	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

eIF4E by CMTR1 expression — UCEC

Explore this box plot interactively →