Q-omics provides the consensus-scored C14orf28 profile across patient tissues and cancer cell-line models. C14orf28 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, C14orf28 is differentially expressed in 14, with the highest sampling consensus in THCA. Additionally, C14orf28 RNA expression shows 19,751 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight UCEC, THCA, and ACC as cancer lineages where C14orf28 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C14orf28 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C14orf28 survival associations across molecular data types. C14orf28 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C14orf28 RNA expression–survival associations across cancer types. High C14orf28 expression shows unfavorable associations in MESO and ACC, but favorable associations in UCEC, BRCA, ESCA and SKCM. The UCEC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCEC as the clearest survival context for C14orf28 RNA expression.
This table summarizes C14orf28 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for C14orf28. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C14orf28 shows lower tumor expression in THCA, BLCA, COAD, UCEC, LUAD and BRCA. The THCA box plot shows higher C14orf28 RNA expression in normal versus tumor tissue (log2 FC = −0.560, t-test p < 0.001).
This table shows molecular features associated with C14orf28 in patient tissues and cancer cell lines. In patient samples, C14orf28 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, C14orf28 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and BLOOD_Lymphoma.
