C14orf28

Across TCGA patient cohorts, C14orf28 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C14orf28-associated genes across cancer lineages are EGFR_pY1068, ERK2, and ACC1. Each is linked with C14orf28 in more than 1 cancer types. Because this analysis shows association rather than direction, both C14orf28-to-partner and partner-to-C14orf28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by C14orf28-low versus C14orf28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C14orf28→partner) and Y-score (partner→C14orf28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.252	-1.847	.006	.008	3	1
UCEC	ERK2 →	+0.198	+1.847	.005	.008	3	1
UCEC	ACC1 →	+0.303	+1.502	.023	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.153	-1.700	.013	.042	3	1
UCEC	MAPK_pT202_Y204 →	-0.339	-1.700	.049	.042	3	1
UCEC	mTOR_pS2448 →	-0.128	-2.687	.019	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR_pY1068 by C14orf28 expression — UCEC

Explore this box plot interactively →