C14orf28

Across TCGA pan-cancer cohorts, C14orf28 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated C14orf28 data layer compared with 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher C14orf28 RNA is associated with better overall survival. In most high-consensus cancer types, elevated C14orf28 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BRCA show a favorable association.

UCEC, MESO, and BRCA are the cancer types where C14orf28 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.874	0.671	<.001	100	view →
MESO	DFS	Median	All	0.283	0.487	.001	60	view →
BRCA	OS	Median	III,IV	0.901	0.749	<.001	56	view →
ACC	DFS	Median	All	0.281	0.629	.001	46	view →
ESCA	OS	Tertile	II,III,IV	0.630	0.360	.005	44	view →
SKCM	DFS	Quartile	All	0.717	0.544	<.001	39	view →
SCLC	OS	Median	All	0.452	0.698	.002	36	view →
PAAD	OS	Median	All	0.593	0.387	.003	28	view →
LAML	DFS	Median	All	0.697	0.441	.011	28	view →
KIRC	DFS	Quartile	All	0.901	0.684	.001	24	view →
THYM	DFS	Median	All	0.941	0.792	.005	22	view →
UCS	DFS	Tertile	IV	0.981	0.321	.024	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

C14orf28–UCEC (OS)

Open the UCEC breakdown →