C14orf28

Across TCGA pan-cancer cohorts, C14orf28 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of C14orf28’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where C14orf28 RNA is repressed in tumor relative to normal tissue. In most cancer types C14orf28 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, BLCA, and COAD are the cancer types where C14orf28 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C14orf28 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.560	<.001	11	view →
BLCA	Male	III,IV	−1.258	.001	8	view →
COAD	All	All	−0.491	<.001	7	view →
UCEC	All	III,IV	−1.665	<.001	6	view →
LUAD	Female	III,IV	−0.635	<.001	6	view →
BRCA	All	All	−0.584	<.001	6	view →
LUSC	All	All	−0.381	<.001	6	view →
STAD	All	All	−0.476	.002	5	view →
LIHC	All	II,III,IV	+0.325	.007	4	view →
READ	All	III,IV	−0.465	.036	2	view →
PRAD	All	All	−0.253	<.001	2	view →
KIRC	All	All	+0.198	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

C14orf28–THCA

Open the THCA breakdown →