bone morphogenetic protein receptor type 1AGenealiases: 10q23del · ACVRLK3 · ALK-3 · ALK3 · BMPR-1A · CD292
Q-omics provides the consensus-scored BMPR1A profile across patient tissues and cancer cell-line models. BMPR1A expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, BMPR1A is differentially expressed in 15, with the highest sampling consensus in THCA. Additionally, BMPR1A RNA expression shows 20,248 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight UCS, THCA, and KIRP as cancer lineages where BMPR1A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for BMPR1A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes BMPR1A survival associations across molecular data types. BMPR1A RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible BMPR1A RNA expression–survival associations across cancer types. High BMPR1A expression shows unfavorable associations in ACC, LIHC and KICH, but favorable associations in UCS, KIRC and LGG. The UCS Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify UCS as the clearest survival context for BMPR1A RNA expression.
This table summarizes BMPR1A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 2. The strongest signals are observed in THCA for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for BMPR1A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. BMPR1A shows lower tumor expression in THCA, KICH, LUAD, BRCA and KIRC and higher tumor expression in LIHC. The THCA box plot shows higher BMPR1A RNA expression in normal versus tumor tissue (log2 FC = −1.204, t-test p < 0.001).
This table shows molecular features associated with BMPR1A in patient tissues and cancer cell lines. In patient samples, BMPR1A shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, BMPR1A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Lymphoma, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and LUNG_NSCLC_LUAD.
