BMPR1A

Across TCGA cell cohorts, BMPR1A mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BMPR1A-associated genes across cancer lineages are AGI-6780, 50869, and CX-5461. Each is linked with BMPR1A in more than 1 cancer types. Because this analysis shows association rather than direction, both BMPR1A-to-partner and partner-to-BMPR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGI-6780 grouped by BMPR1A-low versus BMPR1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMPR1A→partner) and Y-score (partner→BMPR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AGI-6780 →	+0.473	+2.646	.013	.047	3	1
LARGE_INTESTINE	50869 →	+0.533	+2.710	.010	.027	3	1
LARGE_INTESTINE	CX-5461 →	+0.721	+2.652	.013	.045	3	1
LARGE_INTESTINE	Sinularin →	+0.327	+2.777	.038	.038	2	1
LARGE_INTESTINE	EPZ004777 →	+0.368	+2.893	.019	.034	1	1
LARGE_INTESTINE	GSK2606414 →	+0.569	+2.769	.002	.040	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

AGI-6780 by BMPR1A expression — LARGE_INTESTINE

Explore this box plot interactively →